Journal of Current Researches on Engineering, Science and Technology (JoCREST)

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Abstract


Synthesis and Characterization of Donepezil HCL Tablets for Drug Delivery

The use of nanomaterials is increasing day by day because of their superior features. Among the developed and studied nanomaterials, hydroxyapatite (Ca5(PO4)3(OH), HAp) has attracted much attention as a drug carrier medium in controlled drug release applications due to its non-toxicity, mechanical strength and excellent biocompatibility proporties. In this study, the release kinetics of the active ingredient Donepezil Hydrochloride (active pharmaceutical ingredient for Alzheimer's disease) using calcined and uncalcined hydroxyapatite was investigated. Additionally, the release properties of commercially purchased HAP (5µm, surface area≥100 m2/g) and synthesized hydroxyapatite at nano-size were compared. In order to improve release kinetics, tablets with different contents by adding PEG 1500, titanium dioxide, Carbopol 974 and gelatin were obtained. Characterization of the prepared composites was achieved by using Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), and X-Ray diffractometer (XRD). The release of Donepezil Hydrochloride active ingredient from the prepared composite tablets with different properties was examined in vitro experiments at pH 1.2, pH 6.8 (anterior intestine) and pH 7.4 and it was observed that it gave good results in controlled drug release systems. The data obtained confirm the controlled release of Donepezil hydrochloride. Drug release profiles are evaluated according to four different kinetic models including Zero Order, First Order, Higuchi and Korsmeyer-Peppas. When the Drug release profiles were examined, it was observed that each tablet gave different results in different pH environments. With this study, it is aimed to to contribute to controlled drug release studies.



Keywords
Hydroxyapatite, Donepezil hydrochloride, Controlled drug release



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